Assay Detail
Functional
CHEMBL4606644
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Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as reduction in viral DNA levels incubated for 6 days by PCR analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (1H-Pyrazolo[3,4-c]pyridin-5-yl)sulfonamide Analogues as Hepatitis B Virus Capsid Assembly Modulators by Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.20 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 10.19 |
| CHEMBL4647919 | — | — | 1 | 8.46 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 8.42 |
| CHEMBL3742114 | — | — | 1 | 8.18 |
| CHEMBL4647397 | — | — | 1 | 7.38 |
| CHEMBL4637119 | — | — | 1 | 6.55 |
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 0.064 | nM | 10.19 |
| CHEMBL4647919 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3742114 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4647397 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4637119 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5314362 | ENTECAVIR | EC50 | = | 0.0022 | nM | - |