Assay Detail
Functional
CHEMBL989959
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against R5-HIV1MDR/G assessed as inhibition of p24 Gag protein production in human PHA-PBMC by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.07 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517231 | ISLATRAVIR | 3.0 | 1 | 7.68 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.58 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 7.06 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.60 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517231 | ISLATRAVIR | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 380.0 | nM | 6.42 |