Assay Detail
Functional
CHEMBL948343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Moloney murine leukemia virus |
| Cell Type | C3H/3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Moloney murine leukemia virus (CHEMBL613500) ↗| Type | ORGANISM |
| Organism | Moloney murine leukemia virus |
Publication
Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.54 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.64 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 6.28 |
| CHEMBL469886 | — | — | 1 | 6.05 |
| CHEMBL512684 | — | — | 1 | 6.00 |
| CHEMBL511619 | — | — | 1 | 5.96 |
| CHEMBL470688 | — | — | 1 | 5.66 |
| CHEMBL470689 | — | — | 1 | 5.23 |
| CHEMBL450901 | — | — | 1 | 5.08 |
| CHEMBL504460 | — | — | 1 | 4.32 |
| CHEMBL487410 | — | — | 1 | 4.20 |
| CHEMBL469885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL469886 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL512684 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL511619 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL470688 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL470689 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL450901 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL504460 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL487410 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL469885 | — | EC50 | > | 20000.0 | nM | - |