Assay Detail
Functional
CHEMBL1832283
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Antiviral activity against Herpes simplex virus type 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.55 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 4.70 |
| CHEMBL1830068 | — | — | 1 | 4.62 |
| CHEMBL1830069 | — | — | 1 | 4.32 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484 | ADEFOVIR | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1830068 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1830069 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | > | 200000.0 | nM | - |