Assay Detail
Binding
CHEMBL1832526
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Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.39 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.64 |
| CHEMBL1830536 | — | — | 1 | 7.92 |
| CHEMBL1830420 | — | — | 1 | 7.46 |
| CHEMBL1830422 | — | — | 1 | 7.39 |
| CHEMBL1830537 | — | — | 1 | 7.38 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.29 |
| CHEMBL1830424 | — | — | 1 | 7.16 |
| CHEMBL1830396 | — | — | 1 | 7.11 |
| CHEMBL1830397 | — | — | 1 | 7.05 |
| CHEMBL3215861 | — | — | 1 | 6.98 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.89 |
| CHEMBL491316 | — | — | 1 | - |
| CHEMBL460963 | — | — | 1 | - |
| CHEMBL489332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1830536 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1830420 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1830422 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL1830537 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1830424 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL1830396 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL1830397 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL3215861 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL98 | VORINOSTAT | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL491316 | — | Ki | - | — | - | |
| CHEMBL460963 | — | Ki | - | — | - | |
| CHEMBL489332 | — | Ki | - | — | - |