Assay Detail
Functional
CHEMBL1833271
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Antiviral activity against HIV1 infected in human CEM-T4 cells assessed as reduction in viral protein p24 production preincubated for 24 hrs measured after 8 days by MTT assay
27
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-T4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Aryl H-phosphonates 17: (N-aryl)phosphoramidates of pyrimidine nucleoside analogues and their synthesis, selected properties, and anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.83 | 8.96 |
| EC90 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830974 | — | — | 2 | 8.96 |
| CHEMBL1830973 | — | — | 2 | 8.64 |
| CHEMBL1830972 | — | — | 2 | 8.62 |
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | — | 1 | 8.00 |
| CHEMBL1830971 | — | — | 2 | 7.70 |
| CHEMBL1831080 | — | — | 2 | 6.70 |
| CHEMBL1830969 | — | — | 2 | 6.22 |
| CHEMBL1830970 | — | — | 2 | - |
| CHEMBL1830975 | — | — | 2 | - |
| CHEMBL1830976 | — | — | 2 | - |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 2 | - |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 2 | - |
| CHEMBL25541 | — | — | 2 | - |
| CHEMBL284348 | DALFAMPRIDINE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830974 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1830973 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1830972 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1830971 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1831080 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1830969 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1830972 | — | EC90 | = | 0.029 | uM | - |
| CHEMBL1830970 | — | EC50 | < | 20.0 | nM | - |
| CHEMBL1830971 | — | EC90 | = | 0.1 | uM | - |
| CHEMBL1830970 | — | EC90 | < | 0.02 | uM | - |
| CHEMBL1830969 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL25541 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL21619 | 2-AMINOPYRIDINE | EC50 | > | 20000.0 | nM | - |
| CHEMBL129 | ZIDOVUDINE | EC50 | < | 2.0 | nM | - |
| CHEMBL1830976 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1830975 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL284348 | DALFAMPRIDINE | EC90 | > | 20.0 | uM | - |
| CHEMBL25541 | — | EC90 | > | 20.0 | uM | - |
| CHEMBL21619 | 2-AMINOPYRIDINE | EC90 | > | 20.0 | uM | - |
| CHEMBL129 | ZIDOVUDINE | EC90 | = | 0.005 | uM | - |
| CHEMBL1831080 | — | EC90 | = | 1.35 | uM | - |
| CHEMBL1830976 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1830975 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1830974 | — | EC90 | = | 0.006 | uM | - |
| CHEMBL284348 | DALFAMPRIDINE | EC50 | > | 20000.0 | nM | - |
| CHEMBL1830973 | — | EC90 | = | 0.009 | uM | - |