Assay Detail
Binding
CHEMBL1833642
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Inhibition of COX1-mediated 12-HHT production in human platelet after 5 mins by HPLC analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.76 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830480 | — | — | 1 | 7.85 |
| CHEMBL1830471 | — | — | 1 | 7.39 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.16 |
| CHEMBL1830478 | — | — | 1 | 6.52 |
| CHEMBL1830479 | — | — | 1 | 6.05 |
| CHEMBL1830468 | — | — | 1 | 5.60 |
| CHEMBL1830335 | — | — | 1 | - |
| CHEMBL1830338 | — | — | 1 | - |
| CHEMBL1830459 | — | — | 1 | - |
| CHEMBL1830477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830480 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1830471 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1830478 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1830479 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1830468 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1830335 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1830338 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1830459 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1830477 | — | IC50 | > | 10000.0 | nM | - |