Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1833708

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-3 adrenergic receptor (CHEMBL246)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.
Baker JG, Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B.
J Med Chem (2011) 54 : 6874 -6887
PubMed 21870877 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 17 6.94 7.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1830485 1 7.35
CHEMBL1830617 1 7.33
CHEMBL1830487 1 7.17
CHEMBL1830493 1 7.16
CHEMBL1830490 1 7.11
CHEMBL1830619 1 7.09
CHEMBL1830491 1 7.09
CHEMBL1830488 1 7.03
CHEMBL1830618 1 7.00
CHEMBL1830489 1 6.98
CHEMBL1830486 1 6.91
CHEMBL266195 ALPRENOLOL 2.0 1 6.86
CHEMBL500 PINDOLOL 4.0 1 6.78
CHEMBL27 PROPRANOLOL 4.0 1 6.67
CHEMBL1830492 1 6.53
CHEMBL1830620 1 6.48
CHEMBL1830621 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1830485 Kd = 44.67 nM 7.35
CHEMBL1830617 Kd = 46.77 nM 7.33
CHEMBL1830487 Kd = 67.61 nM 7.17
CHEMBL1830493 Kd = 69.18 nM 7.16
CHEMBL1830490 Kd = 77.62 nM 7.11
CHEMBL1830619 Kd = 81.28 nM 7.09
CHEMBL1830491 Kd = 81.28 nM 7.09
CHEMBL1830488 Kd = 93.33 nM 7.03
CHEMBL1830618 Kd = 100.0 nM 7.00
CHEMBL1830489 Kd = 104.71 nM 6.98
CHEMBL1830486 Kd = 123.03 nM 6.91
CHEMBL266195 ALPRENOLOL Kd = 138.04 nM 6.86
CHEMBL500 PINDOLOL Kd = 165.96 nM 6.78
CHEMBL27 PROPRANOLOL Kd = 213.8 nM 6.67
CHEMBL1830492 Kd = 295.12 nM 6.53
CHEMBL1830620 Kd = 331.13 nM 6.48
CHEMBL1830621 Kd = 380.19 nM 6.42