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Compound Detail

CHEMBL1830620

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O=C(CCCCCNC(=O)COc1ccc(/C=C/c2ccc3n2[B-](F)(F)[N+]2=C(c4cccs4)C=CC2=C3)cc1)NCCNCC(O)COc1cccc2[nH]ccc12

Basic Information

ChEMBL ID CHEMBL1830620
Phase Preclinical
Structure Type MOL
InChI Key XSDXBRNBCVMTEE-JLHYYAGUSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

794.7
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C42H45BF2N6O5S
MW 794.73

Activity Summary

Kd 6 meas. best 7.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Kd 7.52 7.425 30.2 2
Beta-3 adrenergic receptor
CHEMBL246
Kd 6.75 6.615 177.8 2
Beta-1 adrenergic receptor
CHEMBL213
Kd 6.52 6.29 302.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21870877 10.1021/jm2008562 Beta-1 adrenergic receptor 4
21870877 10.1021/jm2008562 Beta-3 adrenergic receptor 3
21870877 10.1021/jm2008562 Beta-2 adrenergic receptor 3

Data from ChEMBL 36 via Core Engine