Assay Detail
Binding
CHEMBL1837219
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Inhibition of human AChE by Ellman's assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.96 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 7.50 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.11 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 5.50 |
| CHEMBL1834063 | — | — | 1 | 5.10 |
| CHEMBL1834067 | — | — | 1 | 5.01 |
| CHEMBL1834074 | — | — | 1 | 5.00 |
| CHEMBL1834068 | — | — | 1 | 4.93 |
| CHEMBL1834064 | — | — | 1 | 4.86 |
| CHEMBL1834069 | — | — | 1 | 4.86 |
| CHEMBL1834073 | — | — | 1 | 4.84 |
| CHEMBL1834060 | — | — | 1 | 4.80 |
| CHEMBL1834061 | — | — | 1 | 4.78 |
| CHEMBL1834066 | — | — | 1 | 4.76 |
| CHEMBL1084213 | — | — | 1 | 4.76 |
| CHEMBL1834062 | — | — | 1 | 4.72 |
| CHEMBL1834071 | — | — | 1 | 4.69 |
| CHEMBL1834078 | — | — | 1 | 4.67 |
| CHEMBL1766151 | — | — | 1 | 4.59 |
| CHEMBL1834075 | — | — | 1 | 4.54 |
| CHEMBL1834077 | — | — | 1 | 4.50 |
| CHEMBL1834070 | — | — | 1 | 4.49 |
| CHEMBL1834079 | — | — | 1 | 4.41 |
| CHEMBL1834072 | — | — | 1 | 4.37 |
| CHEMBL1834065 | — | — | 1 | 4.29 |
| CHEMBL1834076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL95 | TACRINE | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1834063 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1834067 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1834074 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1834068 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL1834064 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL1834069 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL1834073 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL1834060 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1834061 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL1834066 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1084213 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1834062 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1834071 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL1834078 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL1766151 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL1834075 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1834077 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL1834070 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL1834079 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL1834072 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL1834065 | — | IC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL1834076 | — | IC50 | > | 100000.0 | nM | - |