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Assay Detail

CHEMBL1837262

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-N-SH cells assessed as cell viability after 48 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-SH
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-SH (CHEMBL614924)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents.
Reddy MA, Jain N, Yada D, Kishore C, Vangala JR, P Surendra R, Addlagatta A, Kalivendi SV, Sreedhar B.
J Med Chem (2011) 54 : 6751 -6760
PubMed 21851083 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 10.60 10.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1836544 1 10.92
CHEMBL1836543 1 10.90
CHEMBL1836542 1 10.89
CHEMBL1836549 1 10.78
CHEMBL1836541 1 10.73
CHEMBL1836547 1 10.68
CHEMBL1836545 1 10.68
CHEMBL1836550 1 10.45
CHEMBL1836551 1 10.44
CHEMBL165 RESVERATROL 3.0 1 10.39
CHEMBL1836546 1 10.22
CHEMBL1836548 1 10.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1836544 IC50 = 0.012 nM 10.92
CHEMBL1836543 IC50 = 0.0125 nM 10.90
CHEMBL1836542 IC50 = 0.0128 nM 10.89
CHEMBL1836549 IC50 = 0.0166 nM 10.78
CHEMBL1836541 IC50 = 0.0188 nM 10.73
CHEMBL1836547 IC50 = 0.0209 nM 10.68
CHEMBL1836545 IC50 = 0.0207 nM 10.68
CHEMBL1836550 IC50 = 0.0358 nM 10.45
CHEMBL1836551 IC50 = 0.0362 nM 10.44
CHEMBL165 RESVERATROL IC50 = 0.0403 nM 10.39
CHEMBL1836546 IC50 = 0.0609 nM 10.22
CHEMBL1836548 IC50 = 0.0681 nM 10.17