Assay Detail
Functional
CHEMBL1837597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against blood stream form Trypanosoma brucei brucei by resazurin fluorescence-based viability assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.43 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836572 | — | — | 1 | 6.36 |
| CHEMBL1836574 | — | — | 1 | 6.26 |
| CHEMBL1836603 | — | — | 1 | 6.14 |
| CHEMBL1836575 | — | — | 1 | 6.12 |
| CHEMBL1836376 | — | — | 1 | 5.89 |
| CHEMBL1836615 | — | — | 1 | 5.85 |
| CHEMBL1836611 | — | — | 1 | 5.82 |
| CHEMBL1836606 | — | — | 1 | 5.70 |
| CHEMBL1836380 | — | — | 1 | 5.57 |
| CHEMBL1836378 | — | — | 1 | 5.36 |
| CHEMBL1836570 | — | — | 1 | 5.25 |
| CHEMBL1836371 | — | — | 1 | 5.19 |
| CHEMBL1836567 | — | — | 1 | 5.00 |
| CHEMBL1836571 | — | — | 1 | 4.92 |
| CHEMBL1836562 | — | — | 1 | 4.89 |
| CHEMBL1836365 | — | — | 1 | 4.89 |
| CHEMBL1836368 | — | — | 1 | 4.85 |
| CHEMBL1836559 | — | — | 1 | 4.72 |
| CHEMBL1836554 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836572 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1836574 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1836603 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1836575 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1836376 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1836615 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1836611 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1836606 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1836380 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1836378 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1836570 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1836371 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1836567 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1836571 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1836562 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1836365 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1836368 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1836559 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1836554 | — | EC50 | = | 40000.0 | nM | 4.40 |