Assay Detail
Functional
CHEMBL1837820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assay
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.21 | 9.22 |
| Ki | 20 | 8.39 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836324 | — | — | 2 | 9.22 |
| CHEMBL1836319 | — | — | 2 | 9.05 |
| CHEMBL1836322 | — | — | 2 | 9.05 |
| CHEMBL1836331 | — | — | 2 | 8.96 |
| CHEMBL1836329 | — | — | 2 | 8.96 |
| CHEMBL1836317 | — | — | 2 | 8.82 |
| CHEMBL1836330 | — | — | 2 | 8.77 |
| CHEMBL1836326 | — | — | 2 | 8.72 |
| CHEMBL1836316 | — | — | 2 | 8.72 |
| CHEMBL1836327 | — | — | 2 | 8.62 |
| CHEMBL1836318 | — | — | 2 | 8.55 |
| CHEMBL1836332 | — | — | 2 | 8.41 |
| CHEMBL1836103 | — | — | 2 | 8.31 |
| CHEMBL1836323 | — | — | 2 | 8.30 |
| CHEMBL1836328 | — | — | 2 | 8.17 |
| CHEMBL1836321 | — | — | 2 | 8.12 |
| CHEMBL1836325 | — | — | 2 | 8.06 |
| CHEMBL1836315 | — | — | 2 | 7.98 |
| CHEMBL1836314 | — | — | 2 | 7.86 |
| CHEMBL1836320 | — | — | 2 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836324 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1836324 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1836319 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1836322 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1836329 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1836331 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1836322 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1836319 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1836317 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1836330 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1836317 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1836326 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1836316 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1836327 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1836318 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL1836326 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL1836316 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1836332 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1836103 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL1836323 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1836328 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL1836321 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL1836323 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL1836325 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1836321 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL1836315 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL1836314 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL1836332 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL1836315 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL1836325 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1836318 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL1836103 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL1836314 | — | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL1836320 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL1836320 | — | IC50 | = | 98.7 | nM | 7.01 |
| CHEMBL1836327 | — | IC50 | - | — | - | |
| CHEMBL1836328 | — | IC50 | - | — | - | |
| CHEMBL1836329 | — | IC50 | - | — | - | |
| CHEMBL1836330 | — | IC50 | - | — | - | |
| CHEMBL1836331 | — | IC50 | - | — | - |