Assay Detail
Binding
CHEMBL1837869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human CRF1 receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.90 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45187 | — | — | 1 | 9.55 |
| CHEMBL1836947 | — | — | 1 | 9.54 |
| CHEMBL309138 | — | — | 1 | 9.52 |
| CHEMBL1836945 | — | — | 1 | 9.43 |
| CHEMBL1836944 | — | — | 1 | 8.52 |
| CHEMBL1836932 | — | — | 1 | 7.92 |
| CHEMBL568606 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45187 | — | Kd | = | 0.279 | nM | 9.55 |
| CHEMBL1836947 | — | Kd | = | 0.291 | nM | 9.54 |
| CHEMBL309138 | — | Kd | = | 0.303 | nM | 9.52 |
| CHEMBL1836945 | — | Kd | = | 0.373 | nM | 9.43 |
| CHEMBL1836944 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL1836932 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL568606 | — | Kd | = | 14.0 | nM | 7.85 |