Corticotropin-releasing factor receptor 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Corticotropin-releasing factor receptor 1 shows approved-linked disease relevance led by congenital adrenal hyperplasia. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P34998. Start with congenital adrenal hyperplasia, then reuse UniProt P34998 as the stable protein anchor across project notes and exports.
Start with congenital adrenal hyperplasia, then reuse UniProt P34998 as the stable protein anchor across project notes and exports.
Corticotropin-releasing factor receptor 1 shows approved-linked disease relevance led by congenital adrenal hyperplasia. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with congenital adrenal hyperplasia because it currently carries approved-linked support. Linked drugs include CRINECERFONT, VERUCERFONT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCorticotropin-releasing factor receptor 1
Review this target as Corticotropin-releasing factor receptor 1, mapped to UniProt P34998. Sequence length is 415 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Corticotropin-releasing factor receptor 1 as ChEMBL target CHEMBL1800, mapped to UniProt P34998. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Corticotropin-releasing factor receptor 1 is the right protein anchor across sources, using UniProt P34998 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why congenital adrenal hyperplasia is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Corticotropin-releasing factor receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P34998 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Corticotropin-releasing factor receptor 1 |
| UniProt Accession | P34998 |
| Component Type | Protein |
| Sequence Length | 415 aa |
Corticotropin-releasing factor receptor 1
Review this target as Corticotropin-releasing factor receptor 1, mapped to UniProt P34998. Sequence length is 415 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Corticotropin-releasing factor receptor 1 shows approved-linked disease relevance led by congenital adrenal hyperplasia. 5 more disease programs remain visible in the same review block.
Start review with congenital adrenal hyperplasia because it currently carries approved-linked support. Linked drugs include CRINECERFONT, VERUCERFONT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4299295 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL3775796 | 9.74 | Ki | 0.18 | Preclinical |
| CHEMBL3774395 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL498311 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL4299341 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL427807 | 9.66 | EC50 | 0.22 | Preclinical |
| CHEMBL3774868 | 9.66 | Ki | 0.22 | Preclinical |
| CHEMBL3775030 | 9.62 | Ki | 0.24 | Preclinical |
| CHEMBL2370939 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL3774682 | 9.6 | Ki | 0.25 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 75 | 1,330 | 7.4 |
| single protein format | 56 | 397 | 7.3 |
| assay format | 4 | 34 | 6.6 |
| tissue-based format | 3 | 4 | 7.8 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 41 | 322 | 7.3 |
| assay format | 13 | 77 | 7.9 |