Compound Detail
CHEMBL291657
CRINECERFONT 💊 Approved Drug
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💊 Approved Drug
C#CCN(c1nc(-c2cc(C)c(OC)cc2Cl)c(C)s1)[C@@H](CC1CC1)c1ccc(C)c(F)c1
Basic Information
| ChEMBL ID | CHEMBL291657 |
| Name | CRINECERFONT |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IEAKXXNRGSLYTQ-DEOSSOPVSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
7
Known Names
2
Indications
1
Mechanisms
Molecular Properties
483.1
MW (Da)
7.52
ALogP
4
HBA
0
HBD
25.4
PSA (Ų)
0.31
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2024 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | Corticotropin-releasing factor receptor 1 | ✓ | ✓ |
Indications
Adrenal Hyperplasia, Congenital Depressive Disorder
Activity Summary
Ki 1 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 6.62 | 6.62 | 240.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 240.0 | nM | 6.62 | Binding affinity towards human Corticotropin releasing factor receptor 1 by the ... | 15080983 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 15080983 | 10.1016/j.bmcl.2004.02.053 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine