Assay Detail
Binding
CHEMBL1838188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC2/NCOR2 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Histone deacetylase 2/Nuclear receptor corepressor 2 (CHEMBL3885591) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.77 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836144 | — | — | 1 | 8.46 |
| CHEMBL146250 | FR-135313 | -1.0 | 1 | 8.41 |
| CHEMBL1836042 | — | — | 1 | 8.17 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 5.82 |
| CHEMBL1836145 | THAILANDEPSIN B | — | 1 | 5.35 |
| CHEMBL1836142 | THAILANDEPSIN A | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836144 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL146250 | FR-135313 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1836042 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1836145 | THAILANDEPSIN B | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1836142 | THAILANDEPSIN A | IC50 | = | 39000.0 | nM | 4.41 |