Assay Detail
Binding
CHEMBL1838190
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Inhibition of recombinant human HDAC4 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.03 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146250 | FR-135313 | -1.0 | 1 | 6.33 |
| CHEMBL1836042 | — | — | 1 | 4.75 |
| CHEMBL1836145 | THAILANDEPSIN B | — | 1 | 4.66 |
| CHEMBL1836144 | — | — | 1 | 4.38 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | - |
| CHEMBL1836142 | THAILANDEPSIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146250 | FR-135313 | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1836042 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1836145 | THAILANDEPSIN B | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1836144 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL1836142 | THAILANDEPSIN A | IC50 | > | 50000.0 | nM | - |