Assay Detail
Binding
CHEMBL1838343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylscopolamine from human M3 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Efficient conversion of a nonselective norepinephrin reuptake inhibitor into a dual muscarinic antagonist-β₂-agonist for the treatment of chronic obstructive pulmonary disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.20 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836647 | — | — | 1 | 8.66 |
| CHEMBL1836646 | — | — | 1 | 8.60 |
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.44 |
| CHEMBL1836645 | — | — | 1 | 8.00 |
| CHEMBL1836644 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836647 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1836646 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1382 | TOLTERODINE | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1836645 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1836644 | — | Ki | = | 49.0 | nM | 7.31 |