Assay Detail
Functional
CHEMBL1838447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human JMSU1 cells overexpressing wild type FGFR3 after 72 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JMSU1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834657 | INFIGRATINIB PHOSPHATE | 4.0 | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834657 | INFIGRATINIB PHOSPHATE | IC50 | = | 15.0 | nM | 7.82 |