Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1838490

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Aspergillus fumigatus 231 after 48 hrs by microdilution method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Aspergillus fumigatus
Confidence 1 — Organism
Curated By Autocuration

Target

Aspergillus fumigatus (CHEMBL363)
Type ORGANISM
Organism Aspergillus fumigatus

Publication

Synthesis and biological activity of desmethoxy analogues of coruscanone A.
Tichotová L, Matoušová E, Spulák M, Kuneš J, Votruba I, Buchta V, Pour M.
Bioorg Med Chem Lett (2011) 21 : 6062 -6066
PubMed 21903391 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.47 4.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1835085 1 4.81
CHEMBL48886 1 4.50
CHEMBL1835086 1 4.50
CHEMBL1835076 1 4.50
CHEMBL1835077 1 4.50
CHEMBL1835081 1 4.50
CHEMBL1835084 1 4.50
CHEMBL1835083 1 4.50
CHEMBL1835079 1 4.20
CHEMBL1835080 1 4.20
CHEMBL106 FLUCONAZOLE 4.0 1 -
CHEMBL216028 CORUSCANONE A 1 -
CHEMBL1835082 1 -
CHEMBL1835078 1 -
CHEMBL1835075 1 -
CHEMBL1835074 1 -
CHEMBL1835073 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1835085 IC50 = 15620.0 nM 4.81
CHEMBL48886 IC50 = 31250.0 nM 4.50
CHEMBL1835086 IC50 = 31250.0 nM 4.50
CHEMBL1835076 IC50 = 31250.0 nM 4.50
CHEMBL1835077 IC50 = 31250.0 nM 4.50
CHEMBL1835081 IC50 = 31250.0 nM 4.50
CHEMBL1835084 IC50 = 31250.0 nM 4.50
CHEMBL1835083 IC50 = 31250.0 nM 4.50
CHEMBL1835079 IC50 = 62500.0 nM 4.20
CHEMBL1835080 IC50 = 62500.0 nM 4.20
CHEMBL106 FLUCONAZOLE IC50 > 50000.0 nM -
CHEMBL216028 CORUSCANONE A IC50 = 250000.0 nM -
CHEMBL1835082 IC50 = 125000.0 nM -
CHEMBL1835078 IC50 = 125000.0 nM -
CHEMBL1835075 IC50 = 125000.0 nM -
CHEMBL1835074 IC50 > 125000.0 nM -
CHEMBL1835073 IC50 = 250000.0 nM -