Assay Detail
Functional
CHEMBL1838752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Increase of EAAT2 expression in mouse primary astrocytes after 24 hrs by Western blot analysis relative to beta-actin protein expression
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Astrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.62 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834147 | — | — | 1 | 6.30 |
| CHEMBL1834143 | — | — | 1 | 5.77 |
| CHEMBL1834157 | — | — | 1 | 5.72 |
| CHEMBL1834154 | — | — | 1 | 5.62 |
| CHEMBL1834131 | — | — | 1 | 5.58 |
| CHEMBL1834177 | — | — | 1 | 5.58 |
| CHEMBL1834164 | — | — | 1 | 5.58 |
| CHEMBL1834133 | — | — | 1 | 5.57 |
| CHEMBL1834129 | — | — | 1 | 5.48 |
| CHEMBL1834168 | — | — | 1 | 5.48 |
| CHEMBL1834127 | — | — | 1 | 5.41 |
| CHEMBL1834155 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834147 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1834143 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1834157 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1834154 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1834131 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1834177 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1834164 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1834133 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1834129 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1834168 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1834127 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1834155 | — | EC50 | = | 4700.0 | nM | 5.33 |