Compound Detail
CHEMBL1834131
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Basic Information
| ChEMBL ID | CHEMBL1834131 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KMSLNRLJPMUXIL-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
315.4
MW (Da)
4.11
ALogP
4
HBA
0
HBD
38.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Astrocyte CHEMBL614871 | EC50 | 5.58 | 5.58 | 2600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Astrocyte | EC50 | = | 2600.0 | nM | 5.58 | Increase of EAAT2 expression in mouse primary astrocytes after 24 hrs by Western... | 21875806 |
| Astrocyte | EC50 | = | 2600.0 | nM | 5.58 | Increase of EAAT2 expression in mouse primary astrocytes after 24 hrs by Western... | 21875806 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21875806 | 10.1016/j.bmcl.2011.08.009 | Astrocyte | 8 |
Data from ChEMBL 36 via Core Engine