Assay Detail

CHEMBL1839007

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ADMET

Cytostatic activity against human HL60 cells after 72 hrs by XTT assay

ChEMBL ↗

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Target

HL-60 (CHEMBL383) ↗

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Primary target HL-60

CHEMBL383

Anchored from Assay target.

Protein identity HL-60

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	HL-60
Confidence	1 — Organism
Curated By	Autocuration

Target

HL-60 (CHEMBL383) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and biological activity of desmethoxy analogues of coruscanone A.

Tichotová L, Matoušová E, Spulák M, Kuneš J, Votruba I, Buchta V, Pour M.
Bioorg Med Chem Lett (2011) 21 : 6062 -6066
PubMed 21903391 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.35	5.35

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL216028	CORUSCANONE A	—	1	5.35

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL216028	CORUSCANONE A	IC50	=	4500.0	nM	5.35