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Assay Detail

CHEMBL1839146

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Functional
Agonist activity at delta opioid receptor in ICR mouse vas deferens assessed as inhibition of MVD contraction height
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Tissue Vas deferens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Delta-type opioid receptor (CHEMBL3222)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.
Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ.
Bioorg Med Chem (2011) 19 : 6135 -6142
PubMed 21925887 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.14 8.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL688 FENTANYL CITRATE 4.0 1 8.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL688 FENTANYL CITRATE IC50 = 7.2 nM 8.14