Assay Detail
Binding
CHEMBL1839619
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Inhibition of AurB
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 6.07 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836810 | — | — | 1 | 7.37 |
| CHEMBL1836802 | — | — | 1 | 7.08 |
| CHEMBL1836804 | — | — | 1 | 6.89 |
| CHEMBL1836801 | — | — | 1 | 6.84 |
| CHEMBL1836837 | — | — | 1 | 6.71 |
| CHEMBL1836800 | — | — | 1 | 6.63 |
| CHEMBL1836841 | — | — | 1 | 6.62 |
| CHEMBL1836838 | — | — | 1 | 6.52 |
| CHEMBL1836840 | — | — | 1 | 6.47 |
| CHEMBL1836796 | — | — | 1 | 6.25 |
| CHEMBL1836754 | — | — | 1 | 6.18 |
| CHEMBL1836867 | — | — | 1 | 6.12 |
| CHEMBL1836803 | — | — | 1 | 6.08 |
| CHEMBL1836815 | — | — | 1 | 5.91 |
| CHEMBL1836842 | — | — | 1 | 5.65 |
| CHEMBL1836845 | — | — | 1 | 5.60 |
| CHEMBL1836847 | — | — | 1 | 5.60 |
| CHEMBL1836755 | — | — | 1 | 5.59 |
| CHEMBL1836846 | — | — | 1 | 5.56 |
| CHEMBL1836843 | — | — | 1 | 5.53 |
| CHEMBL1836844 | — | — | 1 | 5.34 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.19 |
| CHEMBL1836848 | — | — | 1 | 5.07 |
| CHEMBL1836839 | — | — | 1 | 4.96 |
| CHEMBL1836855 | — | — | 1 | - |
| CHEMBL1836865 | — | — | 1 | - |
| CHEMBL1836864 | — | — | 1 | - |
| CHEMBL1836863 | — | — | 1 | - |
| CHEMBL1836862 | — | — | 1 | - |
| CHEMBL1836812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836810 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1836802 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1836804 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL1836801 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL1836837 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL1836800 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL1836841 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL1836838 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL1836840 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL1836796 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL1836754 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL1836867 | — | IC50 | = | 754.0 | nM | 6.12 |
| CHEMBL1836803 | — | IC50 | = | 837.0 | nM | 6.08 |
| CHEMBL1836815 | — | IC50 | = | 1227.0 | nM | 5.91 |
| CHEMBL1836842 | — | IC50 | = | 2252.0 | nM | 5.65 |
| CHEMBL1836845 | — | IC50 | = | 2501.0 | nM | 5.60 |
| CHEMBL1836847 | — | IC50 | = | 2517.0 | nM | 5.60 |
| CHEMBL1836755 | — | IC50 | = | 2541.0 | nM | 5.59 |
| CHEMBL1836846 | — | IC50 | = | 2739.0 | nM | 5.56 |
| CHEMBL1836843 | — | IC50 | = | 2987.0 | nM | 5.53 |
| CHEMBL1836844 | — | IC50 | = | 4588.0 | nM | 5.34 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 6485.0 | nM | 5.19 |
| CHEMBL1836848 | — | IC50 | = | 8484.0 | nM | 5.07 |
| CHEMBL1836839 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1836805 | — | IC50 | - | — | - | |
| CHEMBL1836806 | — | IC50 | - | — | - | |
| CHEMBL1836807 | — | IC50 | - | — | - | |
| CHEMBL1836808 | — | IC50 | - | — | - | |
| CHEMBL1836809 | — | IC50 | - | — | - | |
| CHEMBL1836811 | — | IC50 | - | — | - | |
| CHEMBL1836861 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1836813 | — | IC50 | - | — | - | |
| CHEMBL1836814 | — | IC50 | - | — | - | |
| CHEMBL1836760 | — | IC50 | < | 13.0 | nM | - |
| CHEMBL1739550 | — | IC50 | < | 13.0 | nM | - |
| CHEMBL1836799 | — | IC50 | < | 13.0 | nM | - |
| CHEMBL1836849 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1836798 | — | IC50 | - | — | - | |
| CHEMBL1836797 | — | IC50 | - | — | - | |
| CHEMBL1836761 | — | IC50 | - | — | - | |
| CHEMBL1836759 | — | IC50 | - | — | - | |
| CHEMBL1836758 | — | IC50 | - | — | - | |
| CHEMBL1836757 | — | IC50 | - | — | - | |
| CHEMBL1836756 | — | IC50 | - | — | - | |
| CHEMBL1836812 | — | IC50 | - | — | - | |
| CHEMBL1836862 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1836863 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1836864 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1836865 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1836855 | — | IC50 | > | 20000.0 | nM | - |