Assay Detail
Binding
CHEMBL1840116
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Inhibition of JAK3
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.14 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261386 | — | — | 1 | 7.11 |
| CHEMBL1834949 | — | — | 1 | 6.14 |
| CHEMBL1835014 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261386 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1834949 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1835014 | — | IC50 | = | 6800.0 | nM | 5.17 |