Assay Detail
Functional
CHEMBL1840291
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Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human O-positive erythrocytes assessed as inhibition of parasite growth by [3H]hypoxanthine incorporation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial activity of physalins B, D, F, and G.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.61 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.40 |
| CHEMBL1215434 | PHYSALIN F | — | 1 | 5.66 |
| CHEMBL504404 | PHYSALIN B | — | 1 | 5.55 |
| CHEMBL1835434 | PHYSALIN G | — | 1 | 5.17 |
| CHEMBL502427 | PHYSALIN D | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1215434 | PHYSALIN F | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL504404 | PHYSALIN B | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1835434 | PHYSALIN G | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL502427 | PHYSALIN D | IC50 | = | 55000.0 | nM | 4.26 |