Assay Detail
ADMET
CHEMBL1908251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Mechanism based inhibition of rabbit cytochrome P450 CYP2E1 measured by 7-EFC O-deethylation activity
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.00 | 4.00 |
| kinact | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908229 | — | — | 2 | 4.00 |
| CHEMBL1908221 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908229 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL1908221 | — | Ki | = | 1000000.0 | nM | - |
| CHEMBL1908221 | — | kinact | = | 0.2 | min-1 | - |
| CHEMBL1908229 | — | kinact | = | 0.12 | min-1 | - |