Assay Detail
ADMET
CHEMBL1908260
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Mechanism based inhibition of rat cytochrome P450 CYP2B1
4
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| mechanism based inhibition | 2 | - | - |
| Ki | 1 | 5.28 | 5.28 |
| kinact | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908211 | — | — | 2 | 5.28 |
| CHEMBL447 | SECOBARBITAL | 4.0 | 1 | - |
| CHEMBL1518369 | CUMENE HYDROPEROXIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908211 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL447 | SECOBARBITAL | mechanism based inhibition | - | — | - | |
| CHEMBL1908211 | — | kinact | = | 1.4 | min-1 | - |
| CHEMBL1518369 | CUMENE HYDROPEROXIDE | mechanism based inhibition | - | — | - |