Assay Detail
Binding
CHEMBL1909086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.79 | 9.75 |
| Ki | 871 | 7.05 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 2 | 10.00 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 2 | 9.38 |
| CHEMBL85 | RISPERIDONE | 4.0 | 2 | 8.97 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | — | 2 | 8.90 |
| CHEMBL1909072 | PIPAMAZINE | 4.0 | 2 | 8.85 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 2 | 8.71 |
| CHEMBL723 | CARVEDILOL | 4.0 | 2 | 8.71 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 2 | 8.59 |
| CHEMBL1385840 | ERGOCORNINE | — | 2 | 8.54 |
| CHEMBL611 | TERAZOSIN | 4.0 | 2 | 8.48 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 8.45 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 2 | 8.35 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 8.34 |
| CHEMBL564 | PROMAZINE | 4.0 | 2 | 8.34 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 2 | 8.31 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 8.30 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 2 | 8.10 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 2 | 8.06 |
| CHEMBL1108 | DROPERIDOL | 4.0 | 2 | 8.01 |
| CHEMBL716 | QUETIAPINE | 4.0 | 2 | 7.87 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 7.72 |
| CHEMBL643 | PROMETHAZINE | 4.0 | 2 | 7.68 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 7.68 |
| CHEMBL1201216 | DAPIPRAZOLE | 4.0 | 2 | 7.52 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 2 | 7.48 |
| CHEMBL395110 | MEPAZINE | 4.0 | 2 | 7.47 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 2 | 7.39 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 7.39 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 2 | 7.38 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.099 | nM | 10.00 |
| CHEMBL2 | PRAZOSIN | IC50 | = | 0.178 | nM | 9.75 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 0.416 | nM | 9.38 |
| CHEMBL707 | DOXAZOSIN | IC50 | = | 0.751 | nM | 9.12 |
| CHEMBL85 | RISPERIDONE | Ki | = | 1.079 | nM | 8.97 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | Ki | = | 1.272 | nM | 8.90 |
| CHEMBL1909072 | PIPAMAZINE | Ki | = | 1.417 | nM | 8.85 |
| CHEMBL723 | CARVEDILOL | Ki | = | 1.966 | nM | 8.71 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 1.949 | nM | 8.71 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 1.964 | nM | 8.71 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | IC50 | = | 2.298 | nM | 8.64 |
| CHEMBL1909072 | PIPAMAZINE | IC50 | = | 2.56 | nM | 8.59 |
| CHEMBL479 | THIORIDAZINE | Ki | = | 2.597 | nM | 8.59 |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 2.873 | nM | 8.54 |
| CHEMBL611 | TERAZOSIN | Ki | = | 3.335 | nM | 8.48 |
| CHEMBL42 | CLOZAPINE | Ki | = | 3.591 | nM | 8.45 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 3.551 | nM | 8.45 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 3.547 | nM | 8.45 |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | = | 4.477 | nM | 8.35 |
| CHEMBL564 | PROMAZINE | Ki | = | 4.532 | nM | 8.34 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 4.547 | nM | 8.34 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 4.692 | nM | 8.33 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4.946 | nM | 8.31 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 4.963 | nM | 8.30 |
| CHEMBL1385840 | ERGOCORNINE | IC50 | = | 5.19 | nM | 8.29 |
| CHEMBL611 | TERAZOSIN | IC50 | = | 6.025 | nM | 8.22 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 6.487 | nM | 8.19 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 7.938 | nM | 8.10 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | = | 8.088 | nM | 8.09 |
| CHEMBL564 | PROMAZINE | IC50 | = | 8.187 | nM | 8.09 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 8.214 | nM | 8.09 |
| CHEMBL1729 | CISAPRIDE | Ki | = | 8.654 | nM | 8.06 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 8.966 | nM | 8.05 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 8.935 | nM | 8.05 |
| CHEMBL1108 | DROPERIDOL | Ki | = | 9.78 | nM | 8.01 |
| CHEMBL716 | QUETIAPINE | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1729 | CISAPRIDE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1108 | DROPERIDOL | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL715 | OLANZAPINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL643 | PROMETHAZINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL716 | QUETIAPINE | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL1201216 | DAPIPRAZOLE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1628227 | DOXEPIN | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL395110 | MEPAZINE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL715 | OLANZAPINE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL643 | PROMETHAZINE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 41.0 | nM | 7.39 |