Assay Detail
Binding
CHEMBL1909205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr))
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Insect cells |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.33 | 6.35 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | — | 2 | 6.35 |
| CHEMBL305660 | EBASTINE | 4.0 | 2 | 5.98 |
| CHEMBL1476898 | CADMIUM ACETATE | — | 2 | 5.93 |
| CHEMBL1458880 | CADMIUM DICHLORIDE | — | 2 | 5.88 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | 5.88 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 2 | 5.78 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | — | 2 | 5.73 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 2 | 5.69 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | 5.68 |
| CHEMBL290106 | BITHIONOL | 4.0 | 2 | 5.67 |
| CHEMBL6067481 | COLISTIN | 4.0 | 2 | 5.65 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 2 | 5.61 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 2 | 5.61 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 5.53 |
| CHEMBL1909056 | COBALT(II) ACETYLACETONATE | — | 2 | 5.50 |
| CHEMBL496 | HEXACHLOROPHENE | 4.0 | 2 | 5.48 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 2 | 5.23 |
| CHEMBL24944 | TRIBROMSALAN | 4.0 | 2 | 5.22 |
| CHEMBL86754 | IODOQUINOL | 2.0 | 2 | 5.07 |
| CHEMBL633 | AMIODARONE | 4.0 | 2 | 5.04 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 2 | 4.95 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 4.88 |
| CHEMBL808 | ECONAZOLE | 4.0 | 2 | 4.86 |
| CHEMBL10 | SB-203580 | — | 2 | 4.72 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 4.71 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 4.71 |
| CHEMBL91 | MICONAZOLE | 4.0 | 2 | 4.56 |
| CHEMBL31184 | BENZO[DEF]CHRYSENE | 0.5 | 2 | 4.38 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 2 | 4.18 |
| CHEMBL515914 | AZARIBINE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | = | 449.3 | nM | 6.35 |
| CHEMBL305660 | EBASTINE | IC50 | = | 1057.5 | nM | 5.98 |
| CHEMBL1476898 | CADMIUM ACETATE | IC50 | = | 1186.0 | nM | 5.93 |
| CHEMBL1458880 | CADMIUM DICHLORIDE | IC50 | = | 1334.0 | nM | 5.88 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 1329.0 | nM | 5.88 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 1669.0 | nM | 5.78 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | IC50 | = | 1878.0 | nM | 5.73 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 2035.2 | nM | 5.69 |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | IC50 | = | 2084.0 | nM | 5.68 |
| CHEMBL290106 | BITHIONOL | IC50 | = | 2147.0 | nM | 5.67 |
| CHEMBL6067481 | COLISTIN | IC50 | = | 2227.0 | nM | 5.65 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2485.0 | nM | 5.61 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 2468.0 | nM | 5.61 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 2949.0 | nM | 5.53 |
| CHEMBL1909056 | COBALT(II) ACETYLACETONATE | IC50 | = | 3174.0 | nM | 5.50 |
| CHEMBL496 | HEXACHLOROPHENE | IC50 | = | 3318.8 | nM | 5.48 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 5947.2 | nM | 5.23 |
| CHEMBL24944 | TRIBROMSALAN | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL86754 | IODOQUINOL | IC50 | = | 8577.0 | nM | 5.07 |
| CHEMBL633 | AMIODARONE | IC50 | = | 9148.0 | nM | 5.04 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 11108.0 | nM | 4.95 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 13084.0 | nM | 4.88 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 13904.0 | nM | 4.86 |
| CHEMBL10 | SB-203580 | IC50 | = | 18896.0 | nM | 4.72 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 19366.0 | nM | 4.71 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 19570.0 | nM | 4.71 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 27430.0 | nM | 4.56 |
| CHEMBL31184 | BENZO[DEF]CHRYSENE | IC50 | = | 41503.0 | nM | 4.38 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 66405.0 | nM | 4.18 |
| CHEMBL2106399 | KITASAMYCIN | IC50 | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | Ki | - | — | - | |
| CHEMBL91 | MICONAZOLE | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | Ki | - | — | - | |
| CHEMBL1909067 | — | IC50 | - | — | - | |
| CHEMBL1909067 | — | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | IC50 | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | Ki | - | — | - | |
| CHEMBL1201139 | MEGESTROL ACETATE | IC50 | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | Ki | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | Ki | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | IC50 | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | Ki | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | IC50 | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL21731 | MAPROTILINE | Ki | - | — | - | |
| CHEMBL21731 | MAPROTILINE | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | - | — | - |