Assay Detail
Binding
CHEMBL1909210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.36 | 9.70 |
| Ki | 871 | 6.67 | 10.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 10.04 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 2 | 9.42 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 2 | 9.04 |
| CHEMBL119443 | ERGONOVINE | 3.0 | 2 | 8.89 |
| CHEMBL1909065 | MADURAMICIN ACID | 2.0 | 2 | 8.87 |
| CHEMBL157138 | LISURIDE | 3.0 | 2 | 8.34 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 2 | 8.30 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 2 | 8.09 |
| CHEMBL1201356 | METHYLERGONOVINE | 4.0 | 2 | 8.03 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | — | 2 | 7.96 |
| CHEMBL19215 | METERGOLINE | 2.0 | 2 | 7.96 |
| CHEMBL1385840 | ERGOCORNINE | — | 2 | 7.72 |
| CHEMBL531 | PERGOLIDE | 4.0 | 2 | 7.40 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 2 | 7.33 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 2 | 6.97 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 6.66 |
| CHEMBL1255834 | BW-723C86 | — | 2 | 6.40 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 6.36 |
| CHEMBL723 | CARVEDILOL | 4.0 | 2 | 6.23 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 6.20 |
| CHEMBL621 | TRAZODONE | 4.0 | 2 | 6.08 |
| CHEMBL81 | RALOXIFENE | 4.0 | 2 | 6.07 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 6.06 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 6.02 |
| CHEMBL728 | PROCHLORPERAZINE | 4.0 | 2 | 5.92 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 5.90 |
| CHEMBL1200558 | BACITRACIN | 4.0 | 2 | 5.87 |
| CHEMBL1909072 | PIPAMAZINE | 4.0 | 2 | 5.86 |
| CHEMBL305660 | EBASTINE | 4.0 | 2 | 5.85 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 2 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442 | ERGOTAMINE | Ki | = | 0.091 | nM | 10.04 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 0.201 | nM | 9.70 |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | = | 0.384 | nM | 9.42 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | = | 0.846 | nM | 9.07 |
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 0.909 | nM | 9.04 |
| CHEMBL119443 | ERGONOVINE | Ki | = | 1.293 | nM | 8.89 |
| CHEMBL1909065 | MADURAMICIN ACID | Ki | = | 1.353 | nM | 8.87 |
| CHEMBL762 | OXYMETAZOLINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL119443 | ERGONOVINE | IC50 | = | 2.845 | nM | 8.55 |
| CHEMBL1909065 | MADURAMICIN ACID | IC50 | = | 2.977 | nM | 8.53 |
| CHEMBL157138 | LISURIDE | Ki | = | 4.594 | nM | 8.34 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 5.021 | nM | 8.30 |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | = | 8.199 | nM | 8.09 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 8.191 | nM | 8.09 |
| CHEMBL1201356 | METHYLERGONOVINE | Ki | = | 9.263 | nM | 8.03 |
| CHEMBL157138 | LISURIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL19215 | METERGOLINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1201356 | METHYLERGONOVINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL128 | SUMATRIPTAN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL19215 | METERGOLINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1385840 | ERGOCORNINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL531 | PERGOLIDE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1065 | METHYSERGIDE | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL1065 | METHYSERGIDE | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL1255834 | BW-723C86 | Ki | = | 400.1 | nM | 6.40 |
| CHEMBL1255834 | BW-723C86 | IC50 | = | 421.1 | nM | 6.38 |
| CHEMBL715 | OLANZAPINE | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL723 | CARVEDILOL | Ki | = | 589.0 | nM | 6.23 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL715 | OLANZAPINE | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL621 | TRAZODONE | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL81 | RALOXIFENE | Ki | = | 846.0 | nM | 6.07 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 869.0 | nM | 6.06 |
| CHEMBL42 | CLOZAPINE | Ki | = | 959.0 | nM | 6.02 |
| CHEMBL728 | PROCHLORPERAZINE | Ki | = | 1205.0 | nM | 5.92 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 1263.0 | nM | 5.90 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 1295.0 | nM | 5.89 |
| CHEMBL621 | TRAZODONE | IC50 | = | 1356.0 | nM | 5.87 |
| CHEMBL1200558 | BACITRACIN | Ki | = | 1354.0 | nM | 5.87 |
| CHEMBL1909072 | PIPAMAZINE | Ki | = | 1367.0 | nM | 5.86 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 1387.0 | nM | 5.86 |
| CHEMBL305660 | EBASTINE | Ki | = | 1417.1 | nM | 5.85 |