Assay Detail
Binding
CHEMBL1912403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GCS activity in human A549 cells assessed as amount of GM1 on the cell membrane after 72 hrs by FL-CTB-based fluorescent microscopy
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of glucosylceramide synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.02 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1911818 | — | — | 1 | 9.52 |
| CHEMBL1911678 | — | — | 1 | 8.70 |
| CHEMBL1911679 | — | — | 1 | 8.70 |
| CHEMBL1911817 | — | — | 1 | 8.70 |
| CHEMBL1911829 | — | — | 1 | 8.40 |
| CHEMBL1911827 | — | — | 1 | 8.30 |
| CHEMBL1911830 | — | — | 1 | 7.92 |
| CHEMBL1911819 | — | — | 1 | 7.89 |
| CHEMBL1911820 | — | — | 1 | 7.30 |
| CHEMBL574645 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1911818 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1911678 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1911679 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1911817 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1911829 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1911827 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1911830 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1911819 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1911820 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL574645 | — | IC50 | = | 16500.0 | nM | 4.78 |