Assay Detail
Functional
CHEMBL1912774
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Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs by spectrometric analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.22 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL591208 | — | — | 1 | 6.10 |
| CHEMBL1521932 | — | — | 1 | 5.75 |
| CHEMBL1497537 | — | — | 1 | 5.66 |
| CHEMBL1910059 | — | — | 1 | 5.62 |
| CHEMBL1910058 | — | — | 1 | 5.47 |
| CHEMBL275260 | — | — | 1 | 5.35 |
| CHEMBL1910060 | — | — | 1 | 5.33 |
| CHEMBL1910057 | — | — | 1 | 5.20 |
| CHEMBL1599555 | — | — | 1 | 5.09 |
| CHEMBL1208820 | — | — | 1 | 4.80 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.80 |
| CHEMBL1910061 | — | — | 1 | 4.71 |
| CHEMBL266997 | — | — | 1 | 4.68 |
| CHEMBL1910056 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL591208 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1521932 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1497537 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1910059 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1910058 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL275260 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1910060 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1910057 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1599555 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1208820 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1910061 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL266997 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL1910056 | — | IC50 | = | 35000.0 | nM | 4.46 |