Assay Detail
Functional
CHEMBL1912889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.31 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1910201 | — | — | 1 | 5.82 |
| CHEMBL1910197 | — | — | 1 | 5.70 |
| CHEMBL1910194 | — | — | 1 | 5.60 |
| CHEMBL1910193 | — | — | 1 | 5.52 |
| CHEMBL1910195 | — | — | 1 | 5.52 |
| CHEMBL1910198 | — | — | 1 | 5.52 |
| CHEMBL1910192 | — | — | 1 | 5.22 |
| CHEMBL1910196 | — | — | 1 | 5.22 |
| CHEMBL1910191 | — | — | 1 | 5.10 |
| CHEMBL1910377 | — | — | 1 | 5.10 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.10 |
| CHEMBL1910190 | — | — | 1 | 5.05 |
| CHEMBL1910200 | — | — | 1 | 4.92 |
| CHEMBL1910199 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1910201 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1910197 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1910194 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1910193 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1910195 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1910198 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1910192 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1910196 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1910191 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1910377 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1910190 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1910200 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1910199 | — | IC50 | = | 13000.0 | nM | 4.89 |