Assay Detail
Binding
CHEMBL1912895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human lysosomal beta-galactosidase assessed as inhibition of hydrolyzed 4-methylumbelliferone production after 30 mins by luminescence spectrophotometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.27 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205982 | — | — | 1 | 6.52 |
| CHEMBL505422 | — | — | 1 | 6.22 |
| CHEMBL461161 | — | — | 1 | 6.16 |
| CHEMBL1911831 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205982 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL505422 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL461161 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1911831 | — | Ki | = | 700.0 | nM | 6.16 |