Assay Detail
Binding
CHEMBL1913618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-NMS from human recombinant M3 receptor expressed in CHO cells after 2 hrs by filter binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.10 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 10.12 |
| CHEMBL1910848 | — | — | 1 | 9.96 |
| CHEMBL1908368 | — | — | 1 | 9.54 |
| CHEMBL1910846 | — | — | 1 | 8.74 |
| CHEMBL1910845 | — | — | 1 | 8.72 |
| CHEMBL1910849 | — | — | 1 | 8.41 |
| CHEMBL1910847 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545181 | TIOTROPIUM BROMIDE | Ki | = | 0.075 | nM | 10.12 |
| CHEMBL1910848 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL1908368 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL1910846 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1910845 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1910849 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1910847 | — | Ki | = | 6.4 | nM | 8.19 |