Assay Detail
Binding
CHEMBL1913619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.99 | 10.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1910848 | — | — | 1 | 10.25 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 10.21 |
| CHEMBL1908368 | — | — | 1 | 9.32 |
| CHEMBL1910846 | — | — | 1 | 8.80 |
| CHEMBL1910849 | — | — | 1 | 8.59 |
| CHEMBL1910847 | — | — | 1 | 7.92 |
| CHEMBL1910845 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1910848 | — | Ki | = | 0.056 | nM | 10.25 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | Ki | = | 0.061 | nM | 10.21 |
| CHEMBL1908368 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL1910846 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1910849 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL1910847 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1910845 | — | Ki | = | 15.0 | nM | 7.82 |