Assay Detail
Binding
CHEMBL1918093
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Inhibition of human p38alpha MAP kinase after 1 hr by FRET analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.96 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916528 | — | — | 1 | 9.89 |
| CHEMBL1916527 | — | — | 1 | 9.59 |
| CHEMBL1916523 | — | — | 1 | 9.57 |
| CHEMBL1916525 | — | — | 1 | 9.55 |
| CHEMBL1916530 | — | — | 1 | 9.34 |
| CHEMBL1916360 | — | — | 1 | 9.31 |
| CHEMBL1916529 | — | — | 1 | 9.30 |
| CHEMBL1916520 | — | — | 1 | 9.28 |
| CHEMBL1916519 | — | — | 1 | 9.23 |
| CHEMBL1916361 | — | — | 1 | 9.14 |
| CHEMBL1738839 | — | — | 1 | 9.09 |
| CHEMBL1916531 | — | — | 1 | 8.05 |
| CHEMBL1916526 | — | — | 1 | 7.96 |
| CHEMBL1916359 | — | — | 1 | 7.85 |
| CHEMBL1916522 | — | — | 1 | 7.85 |
| CHEMBL1916524 | — | — | 1 | 7.77 |
| CHEMBL1916521 | — | — | 1 | 7.54 |
| CHEMBL1916358 | — | — | 1 | 7.43 |
| CHEMBL1916349 | — | — | 1 | 7.39 |
| CHEMBL1916350 | — | — | 1 | 7.18 |
| CHEMBL1916344 | — | — | 1 | 7.17 |
| CHEMBL1916355 | — | — | 1 | 7.11 |
| CHEMBL1916354 | — | — | 1 | 7.09 |
| CHEMBL1916351 | — | — | 1 | 7.05 |
| CHEMBL1916348 | — | — | 1 | 6.85 |
| CHEMBL1914478 | — | — | 1 | 6.84 |
| CHEMBL1916347 | — | — | 1 | 6.83 |
| CHEMBL1916345 | — | — | 1 | 6.71 |
| CHEMBL1916346 | — | — | 1 | 6.48 |
| CHEMBL1916352 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916528 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1916527 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL1916523 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL1916525 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL1916530 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL1916360 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL1916529 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1916520 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL1916519 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL1916361 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL1738839 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL1916531 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1916526 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1916359 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1916522 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1916524 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1916521 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1916358 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1916349 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1916350 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1916344 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1916355 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1916354 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1916351 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1916348 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL1914478 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1916347 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL1916345 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL1916346 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL1916352 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL1916353 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1916356 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1916343 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1916357 | — | IC50 | > | 10000.0 | nM | - |