Assay Detail
Functional
CHEMBL1918324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against pseudo HIV1 infected in human 293T cells after 2 days by luciferase reporter gene assay in presence of human serum albumin
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | 293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.47 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1914564 | — | — | 1 | 7.35 |
| CHEMBL1914460 | — | — | 1 | 6.89 |
| CHEMBL1914562 | — | — | 1 | 6.85 |
| CHEMBL1914559 | — | — | 1 | 6.85 |
| CHEMBL1914563 | — | — | 1 | 6.66 |
| CHEMBL1914560 | — | — | 1 | 6.64 |
| CHEMBL1917876 | — | — | 1 | 6.55 |
| CHEMBL1914561 | — | — | 1 | 6.54 |
| CHEMBL1914553 | — | — | 1 | 6.48 |
| CHEMBL1914555 | — | — | 1 | 6.44 |
| CHEMBL1917875 | — | — | 1 | 6.37 |
| CHEMBL1914551 | — | — | 1 | 6.36 |
| CHEMBL1914552 | — | — | 1 | 6.34 |
| CHEMBL1914550 | — | — | 1 | 6.32 |
| CHEMBL1914556 | — | — | 1 | 6.28 |
| CHEMBL1914557 | — | — | 1 | 6.19 |
| CHEMBL1914558 | — | — | 1 | 6.14 |
| CHEMBL1914554 | — | — | 1 | 5.96 |
| CHEMBL1917874 | — | — | 1 | 5.81 |
| CHEMBL1917872 | — | — | 1 | - |
| CHEMBL1917877 | — | — | 1 | - |
| CHEMBL1917873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1914564 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1914460 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1914562 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1914559 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1914563 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1914560 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1917876 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1914561 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1914553 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1914555 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1917875 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1914551 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1914552 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1914550 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1914556 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1914557 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1914558 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1914554 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1917874 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL1917872 | — | EC50 | - | — | - | |
| CHEMBL1917877 | — | EC50 | - | — | - | |
| CHEMBL1917873 | — | EC50 | - | — | - |