Assay Detail
Functional
CHEMBL1918490
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Inhibition of anti-IgM-stimulated human B cell proliferation assessed as [3H]thymidine incorporation preincubated for 30 mins measured after 3 days
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | B cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.95 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916889 | — | — | 1 | 8.99 |
| CHEMBL1916881 | — | — | 1 | 8.70 |
| CHEMBL1916895 | — | — | 1 | 8.66 |
| CHEMBL1916898 | — | — | 1 | 8.62 |
| CHEMBL1916888 | — | — | 1 | 8.59 |
| CHEMBL1916718 | — | — | 1 | 8.50 |
| CHEMBL1916882 | — | — | 1 | 8.50 |
| CHEMBL1916891 | — | — | 1 | 8.47 |
| CHEMBL1916885 | — | — | 1 | 8.38 |
| CHEMBL1916896 | — | — | 1 | 8.36 |
| CHEMBL1916880 | — | — | 1 | 8.31 |
| CHEMBL1916897 | — | — | 1 | 8.23 |
| CHEMBL1916892 | — | — | 1 | 8.17 |
| CHEMBL1916894 | — | — | 1 | 8.09 |
| CHEMBL1916717 | — | — | 1 | 7.79 |
| CHEMBL1916899 | — | — | 1 | 7.76 |
| CHEMBL1916893 | — | — | 1 | 7.63 |
| CHEMBL1916901 | — | — | 1 | 7.49 |
| CHEMBL1916716 | — | — | 1 | 7.37 |
| CHEMBL1916887 | — | — | 1 | 7.35 |
| CHEMBL1916884 | — | — | 1 | 7.27 |
| CHEMBL1916900 | — | — | 1 | 6.84 |
| CHEMBL1916902 | — | — | 1 | 6.64 |
| CHEMBL1916903 | — | — | 1 | 6.19 |
| CHEMBL1916715 | — | — | 1 | - |
| CHEMBL1916890 | — | — | 1 | - |
| CHEMBL1916886 | — | — | 1 | - |
| CHEMBL1916883 | — | — | 1 | - |
| CHEMBL1916879 | — | — | 1 | - |
| CHEMBL1916719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916889 | — | IC50 | = | 1.02 | nM | 8.99 |
| CHEMBL1916881 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1916895 | — | IC50 | = | 2.17 | nM | 8.66 |
| CHEMBL1916898 | — | IC50 | = | 2.41 | nM | 8.62 |
| CHEMBL1916888 | — | IC50 | = | 2.56 | nM | 8.59 |
| CHEMBL1916718 | — | IC50 | = | 3.165 | nM | 8.50 |
| CHEMBL1916882 | — | IC50 | = | 3.17 | nM | 8.50 |
| CHEMBL1916891 | — | IC50 | = | 3.41 | nM | 8.47 |
| CHEMBL1916885 | — | IC50 | = | 4.12 | nM | 8.38 |
| CHEMBL1916896 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1916880 | — | IC50 | = | 4.88 | nM | 8.31 |
| CHEMBL1916897 | — | IC50 | = | 5.84 | nM | 8.23 |
| CHEMBL1916892 | — | IC50 | = | 6.75 | nM | 8.17 |
| CHEMBL1916894 | — | IC50 | = | 8.08 | nM | 8.09 |
| CHEMBL1916717 | — | IC50 | = | 16.15 | nM | 7.79 |
| CHEMBL1916899 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL1916893 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL1916901 | — | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL1916716 | — | IC50 | = | 43.15 | nM | 7.37 |
| CHEMBL1916887 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL1916884 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL1916900 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1916902 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL1916903 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL1916715 | — | IC50 | - | — | - | |
| CHEMBL1916890 | — | IC50 | - | — | - | |
| CHEMBL1916886 | — | IC50 | - | — | - | |
| CHEMBL1916883 | — | IC50 | - | — | - | |
| CHEMBL1916879 | — | IC50 | - | — | - | |
| CHEMBL1916719 | — | IC50 | - | — | - |