Assay Detail
Functional
CHEMBL1918581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of viral replication after 4-5 days by bioluminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.53 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1914564 | — | — | 1 | 7.82 |
| CHEMBL1914562 | — | — | 1 | 7.70 |
| CHEMBL1917875 | — | — | 1 | 7.43 |
| CHEMBL1914556 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1914564 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1914562 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1917875 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1914556 | — | EC50 | = | 66.0 | nM | 7.18 |