Assay Detail
Functional
CHEMBL1918727
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Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.44 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1914576 | — | — | 1 | 7.50 |
| CHEMBL1914588 | — | — | 1 | 7.19 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 6.80 |
| CHEMBL1914589 | — | — | 1 | 5.84 |
| CHEMBL1914590 | — | — | 1 | 5.72 |
| CHEMBL1914591 | — | — | 1 | 5.64 |
| CHEMBL1914577 | — | — | 1 | 5.47 |
| CHEMBL1914585 | — | — | 1 | 5.46 |
| CHEMBL1914578 | — | — | 1 | 5.46 |
| CHEMBL1914592 | — | — | 1 | 5.34 |
| CHEMBL1914587 | — | — | 1 | 5.22 |
| CHEMBL1914579 | — | — | 1 | 5.18 |
| CHEMBL1914586 | — | — | 1 | 5.03 |
| CHEMBL1914580 | — | — | 1 | 4.96 |
| CHEMBL1914581 | — | — | 1 | 4.82 |
| CHEMBL1914584 | — | — | 1 | 4.77 |
| CHEMBL1173787 | — | — | 1 | 4.37 |
| CHEMBL1914582 | — | — | 1 | 4.34 |
| CHEMBL1914583 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1914576 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1914588 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL28079 | ZAPRINAST | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1914589 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL1914590 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL1914591 | — | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL1914577 | — | EC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL1914585 | — | EC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL1914578 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1914592 | — | EC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL1914587 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1914579 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1914586 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1914580 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1914581 | — | EC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL1914584 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL1173787 | — | EC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL1914582 | — | EC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL1914583 | — | EC50 | = | 53900.0 | nM | 4.27 |