Assay Detail
Binding
CHEMBL1919075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsomal 17beta-HSD2 using [3H]E2 as substrate by HPLC analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL2789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.75 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1917897 | — | — | 1 | 7.72 |
| CHEMBL1917889 | — | — | 1 | 6.88 |
| CHEMBL1917895 | — | — | 1 | 6.81 |
| CHEMBL1917893 | — | — | 1 | 6.62 |
| CHEMBL1917887 | — | — | 1 | 6.58 |
| CHEMBL1917881 | — | — | 1 | 6.56 |
| CHEMBL1917891 | — | — | 1 | 6.54 |
| CHEMBL193726 | — | — | 1 | 6.52 |
| CHEMBL1917898 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1917897 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1917889 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1917895 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL1917893 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL1917887 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL1917881 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL1917891 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL193726 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL1917898 | — | IC50 | = | 307.0 | nM | 6.51 |