Assay Detail
Binding
CHEMBL1919185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as induction of tyrosine amino transferase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Steroidal C-21 mercapto derivatives as dissociated steroids: discovery of an inhaled dissociated steroid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.84 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1473 | FLUTICASONE PROPIONATE | 4.0 | 1 | 9.15 |
| CHEMBL1917413 | — | — | 1 | 7.65 |
| CHEMBL1917414 | — | — | 1 | 7.29 |
| CHEMBL1917253 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1473 | FLUTICASONE PROPIONATE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1917413 | — | EC50 | = | 22.4 | nM | 7.65 |
| CHEMBL1917414 | — | EC50 | = | 50.8 | nM | 7.29 |
| CHEMBL1917253 | — | EC50 | = | 55.6 | nM | 7.25 |