Assay Detail
Binding
CHEMBL1919425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM3 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 155 uM [ATP]
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-3 (CHEMBL5407) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.74 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915641 | — | — | 1 | 7.46 |
| CHEMBL1915442 | — | — | 1 | 7.24 |
| CHEMBL1915438 | — | — | 1 | 7.07 |
| CHEMBL1915448 | — | — | 1 | 6.92 |
| CHEMBL1915638 | — | — | 1 | 6.81 |
| CHEMBL1915640 | — | — | 1 | 6.63 |
| CHEMBL1915433 | — | — | 1 | 6.46 |
| CHEMBL1915644 | — | — | 1 | 6.43 |
| CHEMBL1915639 | — | — | 1 | 6.34 |
| CHEMBL1915445 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915641 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1915442 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1915438 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1915448 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1915638 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL1915640 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL1915433 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL1915644 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL1915639 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL1915445 | — | IC50 | = | 875.0 | nM | 6.06 |