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Target Snapshot

CHEMBL5407 Target Snapshot

Serine/threonine-protein kinase pim-3 · SINGLE PROTEIN · Homo sapiens

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3,950Compounds
429Assays
6Approved Drugs
3,754.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q86V86. Use UniProt Q86V86 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q86V86 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase pim-3 as ChEMBL target CHEMBL5407, mapped to UniProt Q86V86. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase pim-3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5407
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q86V86
Serine/threonine-protein kinase pim-3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase pim-3 is the right protein anchor across sources, using UniProt Q86V86 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSerine/threonine-protein kinase pim-3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ86V86
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase pim-3
UniProt AccessionQ86V86
Component TypeProtein
Sequence Length326 aa

Serine/threonine-protein kinase pim-3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase pim-3, mapped to UniProt Q86V86. Sequence length is 326 aa.

Mapped IDQ86V86
Review nameSerine/threonine-protein kinase pim-3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

6
Approved
6
Phase III
7
Phase II
8
Phase I
Assay Mix

Activity Type Distribution

IC502,561.0
KI1,062.0
EC501.0
KD130.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3623162 11.0 Ki 0.01 Preclinical
CHEMBL3634781 11.0 Ki 0.01 Preclinical
CHEMBL3634783 11.0 Ki 0.01 Preclinical
CHEMBL3652638 11.0 Ki 0.01 Preclinical
CHEMBL4439756 11.0 Ki 0.01 Preclinical
CHEMBL4453890 11.0 Ki 0.01 Preclinical
CHEMBL4469964 11.0 Ki 0.01 Preclinical
CHEMBL3906798 10.96 Ki 0.011 Preclinical
CHEMBL3953164 10.96 Ki 0.011 Preclinical
CHEMBL3634767 10.89 Ki 0.013 Preclinical
Distribution

pChEMBL Value Distribution

95
5.0
108
5.5
147
6.0
162
6.5
156
7.0
299
7.5
270
8.0
239
8.5
154
9.0
79
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
RUCAPARIB
CHEMBL1173055
Approved 2016
Properties Compare Identifier
Assay Landscape

Assay Landscape

429
Total Assays
1,468
Tested Compounds
3
Assay Types
Binding — 398 assays, 1,468 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 323 1,144 7.8
assay format 47 292 8.9
cell-based format 28 32 7.5
Functional — 30 assays, 220 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 28 1 6.8
assay format 2 219 5.9
Toxicity — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 2 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine