Compound Detail
CHEMBL3623162
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Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@](C)(N)CC(F)(F)C1
Basic Information
| ChEMBL ID | CHEMBL3623162 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YLJCMWKIAARCQT-HXUWFJFHSA-N |
4
Targets
5
Activities
2
Assay Types
2
PK Parameters
7
Publications
0
Known Names
Molecular Properties
497.5
MW (Da)
3.61
ALogP
8
HBA
3
HBD
115.1
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 11.0
IC50 2 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-3 CHEMBL5407 | Ki | 11.0 | 11.0 | 0.0 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| MM1.S CHEMBL4296471 | IC50 | 6.05 | 6.05 | 900.0 | 1 |
| ADMET CHEMBL612558 | IC50 | 5.08 | 5.08 | 8400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | - | - | Rattus norvegicus |
| F | - | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-3 | Ki | = | 0.01 | nM | 11.0 | Inhibition of recombinant human PIM3 using FAM-pimtide as substrate after 90 min... | 30715878 |
| Serine/threonine-protein kinase pim-1 | Ki | = | 5.0 | nM | 8.3 | Pim Kinase Binding Activity: PIM-1, -2, and -3 enzymes were generated as fusion ... | - |
| MM1.S | IC50 | = | 900.0 | nM | 6.05 | Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter-Gl... | 30715878 |
| ADMET | IC50 | = | 8400.0 | nM | 5.08 | Inhibition of CYP3A (unknown origin) using testosterone as substrate | 26288695 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30715878 | 10.1021/acs.jmedchem.8b01857 | ADMET | 5 |
| 26288695 | 10.1021/acsmedchemlett.5b00191 | ADMET | 2 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | Serine/threonine-protein kinase pim-1 | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | Serine/threonine-protein kinase pim-2 | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | Serine/threonine-protein kinase pim-3 | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | MM1.S | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine