Assay Detail
Functional
CHEMBL4317002
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Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter-Glo assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.76 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459538 | — | — | 1 | 8.10 |
| CHEMBL4453890 | — | — | 1 | 7.52 |
| CHEMBL3623150 | — | — | 1 | 7.40 |
| CHEMBL3676285 | — | — | 1 | 7.30 |
| CHEMBL3648724 | — | — | 1 | 7.30 |
| CHEMBL4109141 | — | — | 1 | 7.16 |
| CHEMBL4439756 | — | — | 1 | 7.16 |
| CHEMBL3648680 | — | — | 1 | 7.16 |
| CHEMBL4437940 | — | — | 1 | 7.10 |
| CHEMBL3648675 | — | — | 1 | 7.00 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 7.00 |
| CHEMBL3103867 | — | — | 1 | 6.80 |
| CHEMBL4469964 | — | — | 1 | 6.70 |
| CHEMBL4450356 | — | — | 1 | 6.30 |
| CHEMBL3623162 | — | — | 1 | 6.05 |
| CHEMBL4472966 | — | — | 1 | 5.68 |
| CHEMBL4455188 | — | — | 1 | 5.10 |
| CHEMBL4458081 | — | — | 1 | 4.89 |
| CHEMBL4449930 | — | — | 1 | - |
| CHEMBL4449080 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459538 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4453890 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3623150 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3676285 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3648724 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4109141 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4439756 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3648680 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4437940 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3648675 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3103867 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4469964 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4450356 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3623162 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4472966 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4455188 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4458081 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4449930 | — | IC50 | - | — | - | |
| CHEMBL4449080 | — | IC50 | > | 25000.0 | nM | - |